Essay --

Diabetes mellitus is one of the common unhealthinesss of the hormonal system. Diabetes is a disease caused by a number of factors such as due to complete or fond(p) loss of insulin production or complete or partial loss of its action or both. Whatever the type of diabetes, the main tout of entirely types of diabetes is marvelous level of blood glucose termed as hyperglycemia. A disease forming variations in capillarys basement membrane thickening, elevation of hyaloplasm of vessel wall and proliferation cell leading to the vascular complications such as narrowing of the lumen, and early atherosclerosis. Diabetes is found to be related with the elevated genesis of atherosclerosis that affects the arteries involve in the circulation to the heart, brain and lower extremities. As well as diabetic myocardial disease, is one of the complications of diabetes. Diabetes founds to affect about blow million people all over the world. The conditions of diabetes leading to the introduct ion and multiplication of microvascular disorder that is results by the decease of the small blood vessels and macrovascular disorders that results by the destruction of arteries. In diabetic patient the major reason of inability and demolition is the vascular disease mainly atherosclerosis.Diabetes elevates the risk of generating coronary, cerebrovascular and peripheral disease. The alteration in the endothelial wall, vascular smooth muscles and functionally active blood platelets all lead to the pathophysiology progressing to vascular disease. The key factors that are the risk factor for the pathogenesis of vascular complication are elevated blood glucose levels, glucose intolerance, elevated lipid profile and hypertension. Deliberating various long term and threatening diabetic... ...vel also found elevated in the diabetic individuals as compare to the non diabetic individuals. All platelet indices like PLT, PCT, MPV and PDW are associated with the determination of platelet activity, in which elevated MPV and PDW has been enter as main a factor that is associated with the complications of thromboembolic. In antecedent psychoanalyze elevated MPV and PDW has been found with very poor control of glyceamic index. In previous study it is documented that elevated levels of MPV, PDW, and CRP in diabetic female as compare to the male with diabetes, developing thromboembolic complications. Positive relation in in the midst of glyceamic index controlling determining factors (FBG and HbA1c) and the indices of platelets (MPV, PDW) demonstrates that HbA1c and platelets indices can be used as alternate indicator for the diagnosis of diabetic complications in early state.